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Abstract #1790

Regional Brain Myelin Changes in Patients with Single Ventricle Heart Disease

Sadhana Singh1, Bhaswati Roy2, Xiaopeng Song1, Nancy Halnon3, Alan Lewis4, Mary Woo2, Nancy Pike2, and Rajesh Kumar1,5,6,7

1Department of Anesthesiology, University of California Los Angeles, Los Angeles, CA, United States, 2UCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, United States, 3Division of Pediatric Cardiology, University of California Los Angeles, Los Angeles, CA, United States, 4Division of Pediatric Cardiology, Children’s Hospital Los Angeles, Los Angeles, CA, United States, 5Department of Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, 6Department of Bioengineering, University of California Los Angeles, Los Angeles, CA, United States, 7Brain Research Institute, University of California Los Angeles, Los Angeles, CA, United States

Single ventricle heart disease (SVHD) subjects show brain injury in multiple gray and white matter based on MRI procedures. However, the extent of regional myelin integrity in SVHD is unclear. We examined the regional brain myelin integrity in SVHD adolescents using the ratio of T1-weighted and T2-weighted MRI signal intensity, and found decreased values in critical autonomic, mood, and cognitive control sites, functions that are deficient in the condition, likely resulting from hypoxic/ischemic processes.

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