Abstract #1790

Regional Brain Myelin Changes in Patients with Single Ventricle Heart Disease

Sadhana Singh¹, Bhaswati Roy², Xiaopeng Song¹, Nancy Halnon³, Alan Lewis⁴, Mary Woo², Nancy Pike², and Rajesh Kumar^1,5,6,7

¹Department of Anesthesiology, University of California Los Angeles, Los Angeles, CA, United States, ²UCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, United States, ³Division of Pediatric Cardiology, University of California Los Angeles, Los Angeles, CA, United States, ⁴Division of Pediatric Cardiology, Children’s Hospital Los Angeles, Los Angeles, CA, United States, ⁵Department of Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, ⁶Department of Bioengineering, University of California Los Angeles, Los Angeles, CA, United States, ⁷Brain Research Institute, University of California Los Angeles, Los Angeles, CA, United States

Single ventricle heart disease (SVHD) subjects show brain injury in multiple gray and white matter based on MRI procedures. However, the extent of regional myelin integrity in SVHD is unclear. We examined the regional brain myelin integrity in SVHD adolescents using the ratio of T1-weighted and T2-weighted MRI signal intensity, and found decreased values in critical autonomic, mood, and cognitive control sites, functions that are deficient in the condition, likely resulting from hypoxic/ischemic processes.

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