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Abstract #1793

Altered regional brain activities and functional connectivities in children with nonsyndromic cleft and/or lip palate: a resting-state functional MRI study.

Hua CHENG1, BO RAO2, YANG FAN3, YingZi Gao1, WenJing Zhang4, and Yun Peng1

1Imaging Center, Beijing Children's Hospital affiliated to Capital Medical University, Beijing, China, 2Capital Medical University, Beijing, China, 3GE Healthcare, MR Research China, Beijing, China, 4Beijing Stomatological Hospital, Capital Medical University, Beijing, China

Rs-fMRI has been widely used as an effective method to evaluate the brain functional changes in physiological and pathological process. Altered both regional brain activities and functional connectivities, especially in verbal and cognitive areas, were found in children with nonsyndromic CL/P using resting-state fMRI. It helps to understand the abnormality of functional architecture of CL/P which implies different structures and cognitive patterns in CL/P compared with normal development children.

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