Abstract #1809

Assessment of brain volume and shape abnormalities in the major depressive disorders with and without suicidal ideation

Hui-Ming Tseng¹, Vincent Chin-Hung Chen^2,3, Yuan-Hsiung Tsai⁴, and Jun-Cheng Weng^3,5

¹Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, ²School of Medicine, Chang Gung University, Taoyuan, Taiwan, ³Department of Psychiatry/ Health Information and Epidemiology Laboratory, Chang Gung Memorial Hospital, Chiayi, Taiwan, ⁴Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi, Taiwan, ⁵Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan

There is very strong connection between patients with major depressive disorders (MDD) and suicide. We used voxel-based morphometry (VBM) and vertex-wise shape analyses to observe the difference between the MDD patients with and without suicidal ideation in their brain volume of gray and white matter as well as shape. We found the negative correlation between the brain volume of limbic system in MDD patients. We also found the significant difference in brain volume and shape of limbic system between suicidal ideation and non-suicidal ideation.

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