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Abstract #1810

Atypical associations between language comprehension network and attention pathways in autism spectrum disorders

Yu-Chun Lo1,2, Susan Shur-Fen Gau3, Yu-Jen Chen1, Yung-Chin Hsu1, and Wen-Yih Isaac Tseng1

1Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, 2The Ph.D. Program for Neural Regenerative Medicine, Taipei Medical University, Taipei, Taiwan, 3Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan

Impaired language comprehension has been consistently found in autism spectrum disorder (ASD). Development of language comprehension highly corresponds to joint attention and impulsivity. We used diffusion spectrum imaging to measure white matter integrity of the language comprehension network and the attention pathways in 60 ASD and 55 typically developing (TD) boys. ASD showed partially reduced white matter integrity in the targeted tracts as compared to TD. The tract covariance between the language comprehension network and the attention pathways showed different patterns in both groups which may shed light in the relationships of language and attention in ASD.

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