Abstract #1811

Connectome analysis of brain functional network alterations in depressed patients with and without self-harm

Yu-Syuan Chou¹, Vincent Chin-Hung Chen^2,3, Yuan-Hsiung Tsai⁴, Shan-Chih Lee¹, and Jun-Cheng Weng^3,5

¹Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, ²School of Medicine, Chang Gung University, Taoyuan, Taiwan, ³Department of Psychiatry/ Health Information and Epidemiology Laboratory, Chang Gung Memorial Hospital, Chiayi, Taiwan, ⁴Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi, Taiwan, ⁵Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan

We aimed to use resting-state fMRI (rs-fMRI) to investigate the functional connectivity difference between depressed patients with and without self-harm history as well as healthy participants. The graph theoretical analysis (GTA) and network-based statistic (NBS) analysis were also used to find the network difference between each group. In GTA and NBS analyses revealed different topological organization and poor global integration of the brain network in depressed participants compared with healthy participants. We suggested that depressed patients with or without self-harm history may affect their brain functional connectivity.

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