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Abstract #1813

Resting-state brain functional alteration in dorsal attention network associated with post-chemotherapy breast cancer

Chao-Yu Shen1,2,3, Vincent Chin-Hung Chen4,5, Xuan-Ru Zhang2, Meng-Syuan Lin2, Dah-Cherng Yeh6, Yeu-Sheng Tyan2,3, Ming-Chih Chou1,7, and Jun-Cheng Weng5,8

1Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, 2Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, 3Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan, 4School of Medicine, Chang Gung University, Taoyuan, Taiwan, 5Department of Psychiatry/ Health Information and Epidemiology Laboratory, Chang Gung Memorial Hospital, Chiayi, Taiwan, 6Breast Center, Taichung Tzu Chi Hospital, Taichung, Taiwan, 7Division of Thoracic Surgery, Department of Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan, 8Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan

The current study was to investigate post-chemotherapy breast cancer with rs-fMRI using mfALFF analysis and correlated with clinical cognitive testing. The results showed altered brain activity in the dorsal attention network in breast cancer patients compared to healthy controls and the affected areas were associated with MMSE, CAMS-R and IES-R scores.

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