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Abstract #1814

Principal Component Analysis of Schizophrenia Reveals Link Between Auditory Hallucination Severity and Fractional Anisotropy in the Corpus Callosum

Meighen M Roes1, Alexander Mark Weber2, and Todd S Woodward1

1Psychiatry, University of British Columbia, Vancouver, BC, Canada, 2Pediatrics, University of British Columbia, Vancouver, BC, Canada

A PCA analysis of fractional anistropy (FA) was conducted from a sample of schizophrenia patients (n=42) and healthy controls (n=40) resulted in three major components: “corpus callosum”, “internal capsule/temporal/brainstem”, and “corona radiata”. Average component scores did not differ as a function of group, but a correlation of PSYRATS scores and principal components revealed the frequency, amount of distress associated with voices, and disruption associated with voices correlated significantly with the corpus callosum component. Our findings suggest that reduced interhemispheric connectivity of the prefrontal cortex is related to hallucination severity in schizophrenia, perhaps mediated through top-down processes such as source monitoring.

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