Abstract #1815

Diffusion kurtosis imaging and white matter model analysis of the brains of patients with major depressive disorder

Kouhei Kamiya^1,2, Naohiro Okada³, Kingo Sawada³, Yusuke Watanabe¹, Ryusuke Irie^1,2, Yuichi Suzuki⁴, Shohei Hanaoka¹, Takeyuki Watadani¹, Shinsuke Koike³, Harushi Mori¹, Akira Kunimatsu^1,5, Masaaki Hori², Shigeki Aoki², Kiyoto Kasai³, and Osamu Abe¹

¹Department of Radiology, the University of Tokyo, Tokyo, Japan, ²Department of Radiology, Juntendo University, Tokyo, Japan, ³Department of Neuropsychiatry, the University of Tokyo, Tokyo, Japan, ⁴Department of Radiology, the University of Tokyo Hospital, Tokyo, Japan, ⁵Department of Radiology, the Institute of Medical Science, the University of Tokyo, Tokyo, Japan

We investigated the brain microstructural changes in major depressive disorder (MDD) using DKI and biophysical modelling. Twenty-six patients with MDD and 42 healthy control subjects were enrolled. TBSS whole brain analyses showed decrease of MK and RK in the patients as compared to the controls, predominantly in the frontal lobe, but widely distributed in the cerebral white matter. Model analysis revealed smaller intra-axonal volume fraction in the corpus callosum. The present results indicate the ability of DKI to demonstrate MDD pathology that are not fully depicted by DTI, and possibly to provide a new insights into the pathophysiology of MDD.

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