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Abstract #1815

Diffusion kurtosis imaging and white matter model analysis of the brains of patients with major depressive disorder

Kouhei Kamiya1,2, Naohiro Okada3, Kingo Sawada3, Yusuke Watanabe1, Ryusuke Irie1,2, Yuichi Suzuki4, Shohei Hanaoka1, Takeyuki Watadani1, Shinsuke Koike3, Harushi Mori1, Akira Kunimatsu1,5, Masaaki Hori2, Shigeki Aoki2, Kiyoto Kasai3, and Osamu Abe1

1Department of Radiology, the University of Tokyo, Tokyo, Japan, 2Department of Radiology, Juntendo University, Tokyo, Japan, 3Department of Neuropsychiatry, the University of Tokyo, Tokyo, Japan, 4Department of Radiology, the University of Tokyo Hospital, Tokyo, Japan, 5Department of Radiology, the Institute of Medical Science, the University of Tokyo, Tokyo, Japan

We investigated the brain microstructural changes in major depressive disorder (MDD) using DKI and biophysical modelling. Twenty-six patients with MDD and 42 healthy control subjects were enrolled. TBSS whole brain analyses showed decrease of MK and RK in the patients as compared to the controls, predominantly in the frontal lobe, but widely distributed in the cerebral white matter. Model analysis revealed smaller intra-axonal volume fraction in the corpus callosum. The present results indicate the ability of DKI to demonstrate MDD pathology that are not fully depicted by DTI, and possibly to provide a new insights into the pathophysiology of MDD.

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