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Abstract #1827

Alterations in amplitude of low frequency fluctuation in drug-free major depressive disorder

Hu Xiaoxiao1, Hu Xinyu1, Li Hailong1, Zhang Lianqing 1, Lu Lu1, Bu Xuan1, Tang Shi1, Gong Qiyong1, and Huang Xiaoqi1

1Huaxi Magnetic Resonance Research Centre (HMRRC), Department of Radiology, West China Hospital of Sichuan University, chengdu, China

The objective of this study was 1) to confirm whether the intrinsic brain activities (as evaluated by ALFF) in the anterior cingulate cortex (ACC) is associated with antidepressant treatment in a relative large sample of drug-free major depressive disorder (MDD) patients and 2) to determine whether the pretreatment ALFF activities predict the effect of the follow-up antidepressant treatment in MDD. Our findings demonstrate that intrinsic brain activities in the ACC was influenced by disease itself rather than antidepressant treatment and threw light on predictive value of the right thalamus as a marker of short term antidepressant treatment outcome in MDD.

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