The objective of this study was 1) to confirm whether the intrinsic brain activities (as evaluated by ALFF) in the anterior cingulate cortex (ACC) is associated with antidepressant treatment in a relative large sample of drug-free major depressive disorder (MDD) patients and 2) to determine whether the pretreatment ALFF activities predict the effect of the follow-up antidepressant treatment in MDD. Our findings demonstrate that intrinsic brain activities in the ACC was influenced by disease itself rather than antidepressant treatment and threw light on predictive value of the right thalamus as a marker of short term antidepressant treatment outcome in MDD.
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