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Abstract #1828

A pilot study of cerebral blood flow changes in patients undergoing electroconvulsive therapy

Karl D Spuhler1, Laura Kunkel2, Adeeb Yacoub2, Kenneth Wengler1, Xiang He3, and Chuan Huang1,2,3

1Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, 2Psychiatry, Stony Brook Medicine, Stony Brook, NY, United States, 3Radiology, Stony Brook Medicine, Stony Brook, NY, United States

Electroconvulsive therapy (ECT) is an effective choice for patients with untreatable depression. Although it is very effective, the mechanisms through which ECT works are poorly understood. We have previously collected PET/MRI data in patients receiving ECT which suggest that this treatment strongly affects the hippocampus. Herein, we supplement these preexisting data with arterial spin labeling data showing significantly reduced blood flow to the hippocampus following ECT in three responders.

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