Meeting Banner
Abstract #1829

In search for a  neuroimaging marker for neuroinflammation in neuropsychiatric systemic lupus erythematosus

Marjolein Bulk1, Ece Ercan2, Cesar Magro-Checa3, Louise van der Weerd1, and Itamar Ronen1

1Radiology, LUMC, Leiden, Netherlands, 2Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 3Rheumatology, LUMC, Leiden, Netherlands

We explored the link between neuroinflammation and related changes in tissue susceptibility by using quantitative susceptibility mapping (QSM) in a clinically well characterized cohort including inflammatory NP-SLE, ischemic NP-SLE and SLE patients. No significant differences were found after stratifying all patients for antibodies, SLE activity, cumulative SLE damage or complement components in subcortical structures. Subanalysis of inflammatory NP-SLE patients showed a residual correlation between QSM values in the globus palidus and low C1q levels, which need further investigation. Current work is underway to analyse QSM in a bigger sample size to further investigate its potential in identifying NP-SLE patients.

This abstract and the presentation materials are available to members only; a login is required.

Join Here