Trait anxiety is a prone phenotype for the development of anxiety disorders and depression. Therefore, in order to identify the individuals 'at risk', identifying the hallmarks of trait anxiety becomes important. Ones identified, timely preventive interventions may be given to such individuals. This study is an attempt to study the trait anxiety associated metabolic/ neurochemical alterations in the brain using proton magnetic resonance spectroscopy. We obtained an increase in the concentrations of Choline compounds in the thalamus as a function of trait anxiety of the subjects suggesting an altered cell membrane metabolism.