Deficient hippocampus glutamatergic function could underlie cognitive deficits and positive-negative symptoms in schizophrenia (SZ) and bipolar disorder (BP). Using 1H MRS, we found that the glutamate concentration of left anterior hippocampus was significantly lower in SZ (6.3 ± 1.8 mM) vs. healthy controls (HC, 7.8 ± 1.2 mM, p=0.021) and BP (8.5 ± 1.3 mM, p=0.001) and trended higher in BP vs. HC (p=0.179). Decreased glutamate is consistent with deficient excitatory neurotransmission in the hippocampus of patients with SZ, which could alter synaptic plasticity underlying memory and cognition. Our findings are consistent with the glutamate hypothesis of SZ.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords