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Abstract #1833

A meta-analysis of altered resting-state functional activity in medication-naive patients with first-episode major depression versus healthy controls

Xiaoyue Ma1, Jia Liu2, Taiyuan Liu1, Yan Wang1, Meiyun Wang1, and Tianyi Qian3

1Zhengzhou University People’s Hospital & Henan Provincial People’s Hospital& Henan Key Laboratory for Medical Imaging of Neurological Diseases, Zhengzhou, China, 2Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 3Siemens Healthcare, MR Collaboration NE Asia, Beijing, China

This study aimed to use the voxel-based meta-analytic technique called anisotropic effect size-signed differential mapping (AES-SDM) to determine consistent regional brain activity alterations in medication-naive patients with first-episode unipolar major depression disorder (MDD) versus healthy controls (HCs). The pooled and subgroup meta-analyses found that MDD patients showed resting-state brain decreased activity in the left anterior lobe of the cerebellum and increased activity in the left amygdala and left hippocampus which have hitherto been neglected in previous studies and provide new implications for the pathophysiology of cognitive and emotional impairment in MDD patients.

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