This study aimed to use the voxel-based meta-analytic technique called anisotropic effect size-signed differential mapping (AES-SDM) to determine consistent regional brain activity alterations in medication-naive patients with first-episode unipolar major depression disorder (MDD) versus healthy controls (HCs). The pooled and subgroup meta-analyses found that MDD patients showed resting-state brain decreased activity in the left anterior lobe of the cerebellum and increased activity in the left amygdala and left hippocampus which have hitherto been neglected in previous studies and provide new implications for the pathophysiology of cognitive and emotional impairment in MDD patients.
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