Abstract #1834

Neurometabolic alterations in patients with major depression measured with short echo-time whole-brain MR spectroscopic imaging

Xiao-Qi Ding¹, Sirin Atalay ², Andrew A Maudsley³, Sulaiman Sheriff ³, Anna Cummings², Birte Schmitz¹, Heinrich Lanfermann ¹, and Kai G Kahl²

¹Institute of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Germany, ²Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany, ³Department of Radiology, University of Miami School of Medicine, Miami, FL, United States

Major depressive disorder (MDD) is a common mental disorder with unclear pathophysiology. Metabolite concentrations over brain lobes or cerebellum in patients with MDD were studied. The results revealed that brain metabolic alterations associated with MDD were related to brain region and metabolite, and were particularly present in right and left frontal lobes. The findings indicate neuronal dysfunction and altered glutamatergic neuronal activity in patients.

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