Meeting Banner
Abstract #1835

Longitudinal structural white matter alterations in adolescents at risk for psychopathology: a Randomised Controlled Trial.

Stijn Michielse1, Jindra Bakker1, Iris Lange1, Liesbet Goossens1, Koen Schruers1,2, Ritsaert Lieverse1, Therese van Amelsvoort1, Marieke Wichers3, Jim van Os1,4,5, and Machteld Marcelis1,6

1Psychiatry & Neuropsychology, Maastricht University, Maastricht, Netherlands, 2Faculty of Psychology, University of Leuven, Leuven, Belgium, 3Department of Psychiatry, University Medical Center Groningen, Groningen, Netherlands, 4Department of Psychosis Studies, Institute of Psychiatry, King’s College London, London, United Kingdom, 5f. Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands, 6Institute for Mental Health Care, Eindhoven, Netherlands

This project is an RCT in 51 individuals with mild psychopathology randomly assigned to Acceptance and Commitment Therapy (ACT) or topic discussion group conditions. Participants underwent Diffusion Weighted Imaging (DWI), Experience Sampling Method (ESM) and a Community Assessment of Psychic Experiences (CAPE) questionnaire before and after intervention. Results show no differences between conditions after the intervention in the white matter (DWI) or the amount of psychotic experiences (CAPE). The suspicious mood ESM item showed was significantly changed due to ACT-intervention. Therefore white matter changes do not seem to occur, while mood changes as a result after 12 week intervention.

This abstract and the presentation materials are available to members only; a login is required.

Join Here