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Abstract #1840

White Matter Abnormalities in Never-Treated Patients with Long Term Schizophrenia

Yuan Xiao1, Huaiqiang Sun1, Bo Tao1, Youjin Zhao1, Wenjing Zhang1, Qiyong Gong1, John Adrian Sweeney2, and Su Lui1

1Dept. of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2Dept. of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, United States

Do white matter abnormalities increase over the long-term course of schizophrenia, and is their trajectory influenced by antipsychotic treatment? In this cross-sectional study, more alteration of white matter microstructure were found in long-term but never-treated schizophrenia patients than duration-matched chronically treated patients. In the genu of the corpus callosum, there was an accelerated age-related reduction of fiber tract integrity in the never-treated patients. The more attenuated white matter changes in the treated patient group suggests that long-term antipsychotic treatment may have a neuroprotective effect on white matter tracts.

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