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Abstract #1839

Voxel-based morphometry using silent T1-weighted sequence elucidates the brain volume difference between autism spectrum disorder and children with typical development

Yoshiyuki Watanabe1, Masahiro Fujiwara1, Takuya Fujiwara1, Hiroto Takahashi1, Hisashi Tanaka1, Kuriko Shimono2, Mariko Nakanishi2, Ryuzo Hanaie2, Ikuko Mohri2, and Noriyuki Tomiyama1

1Radiology, Osaka University, Suita, Japan, 2United Graduate School of Child Development, Osaka University, Suita, Japan

Silent MR sequences are expected to be useful and promising in the evaluation of hyperacusia patients, especially autism spectrum disorder (ASD). The aim of this research was to apply silent T1W to evaluate the brain volume changes between ASD and children with typical development (TD). Results showed that the brain volume of ASD was significantly increased at the left inferior temporal lobe and the right cerebellar tonsils and decreased at the right insular cortex and the right medial frontal lobe compared to that of TD. Silent T1W sequence can detect brain volume difference between ASD and TD.

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