Heroin-induced white matter integrity disruption and the restorability during long-term abstinence have been reported. However, the characteristic of these recover during different stage of abstinence has not been well understood. Use the voxel-wised diffusion tensor method，we compared the white matter difference within 17 long-term abstinence heroin addicts (LA), 22 short-term abstainers (SA) and 20 healthy controls (HC). We found significantly decreased white matter integrity in SA and the time-dependent recover of white matter integrity, especially the restoration of myelin sheath, in LA,. These structural recover may contributed to the improvement of function in the duration of long-term abstinence.
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