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Abstract #1846

The Observable Fraction of Myelin Lipid 1H Magnetization Imaged by IR-ZTE

Alan C Seifert1,2, Michael J Wilhelm3, Suzanne L Wehrli4, and Felix W Wehrli1

1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Department of Chemistry, Temple University, Philadelphia, PA, United States, 4SAIF Core Facility, Children's Hospital of Philadelphia, Philadelphia, PA, United States

Direct detection of myelin using solid-state imaging methods is challenging due to the extremely short lifetime of the myelin matrix 1H MR signal, which significantly limits its observability. In this work, the fraction of total myelin matrix 1H MR signal that is observable by an inversion-recovery (IR)-prepared zero echo-time (ZTE) imaging with pointwise encoding time reduction with radial acquisition (PETRA) sequence using various acquisition parameters is estimated by Bloch equation simulations. Only approximately 5% of total magnetization is observable under realistic experimental conditions. The adiabatic inversion-recovery pulse is mostly responsible for this low fractional observability.

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