Direct detection of myelin using solid-state imaging methods is challenging due to the extremely short lifetime of the myelin matrix 1H MR signal, which significantly limits its observability. In this work, the fraction of total myelin matrix 1H MR signal that is observable by an inversion-recovery (IR)-prepared zero echo-time (ZTE) imaging with pointwise encoding time reduction with radial acquisition (PETRA) sequence using various acquisition parameters is estimated by Bloch equation simulations. Only approximately 5% of total magnetization is observable under realistic experimental conditions. The adiabatic inversion-recovery pulse is mostly responsible for this low fractional observability.
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