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Abstract #1847

Magnetic Resonance Imaging (MRI) Assessment of Dimethyl Fumarate in Protecting Myelin in a Cuprizone Mouse Model

Peter Cheng-te Chou1, Benxiu Ji2, Jon Archbold1, Ankur Thomas2, Davide Gianni2, Daniel Bradley1, Haiying Liu1, and Brian Wipke2

1Research and Early Development Biomarker, Biogen, Cambridge, MA, United States, 2Neuroimmunology and Acute Neurology Research Unit, Biogen, Cambridge, MA, United States

Multiple sclerosis (MS) is a debilitating disease that affects the central nervous system. Immune system destroys the myelin that protects the axon which leads to physical, neurocognitive, and psychiatric disorders. Symptoms may improve, but permanent neurological problems often remain. There is no known cure for MS but current treatments can improve symptoms and prevent relapse. MRI has a role in MS diagnosis and management. We demonstrated that advances in MRI techniques such as Magnetization Transfer Ratio Imaging and Diffusion Tensor Imaging can detect the protective effects of dimethyl fumarate, clinically approved MS treatment, in the corpus callosum of mice.

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