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Abstract #1849

Three-Dimensional Inversion Recovery Ultrashort Echo Time (3D IR-UTE) Magnetic Resonance Imaging of Myelin in Rats and Mice Subject to Cuprizone Treatment

Yajun Ma1, Adam Searleman 1, Robert Bussell1, Eric Y Chang1,2, Srihari Sampath3, Srinath Sampath3, Lisa Deaton3, Andrew Shumacher3, and Jiang Du1

1University of California, San Diego, San Diego, CA, United States, 2VA San Diego Healthcare System, San Diego, CA, United States, 3Genomics Institute of the Novartis Research Foundation (GNF), San Diego, CA, United States

Ultrashort echo time (UTE) MRI is capable of directly imaging myelin protons. We present the first application of a UTE sequence to study an animal model of demyelination, using inversion recovery (IR) and 3D radial sampling. Mice treated with 0.2% cuprizone for 5 weeks show loss of the 3D IR-UTE signal in the lateral corpus callosum, which is expected to be maximally demyelinated at this time point. Future studies of histologically validated demyelination and remyelination in this model will further confirm the capability of 3D IR-UTE to selectively image myelin.

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