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Abstract #1850

Measurement of T1 and T2* Relaxation Times of Purified Animal Myelin by 3D UTE Cones Sequences at 3T

Adam Cory Searleman1, Yajun Ma1, Eric Y Chang1,2, and Jiang Du1

1Radiology, University of California San Diego, La Jolla, CA, United States, 2Radiology, VA San Diego Healthcare System, San Diego, CA, United States

Determination of accurate T1 and T2* values of myelin protons is challenging because it is comprised of multiple lipid and protein components with an ultrashort T2*, but would be important for ultrashort echo time (UTE) sequence development. In this study, we present the first T1 and T2* measurements of intact myelin directly purified from white matter, with T1 measured using a 3D UTE Cones adaptation of actual flip-angle imaging (UTE-AFI) with variable TRs, and T2* measured using 3D UTE acquisitions with variable TEs. We find that myelin has a T1 of 367 ms and T2* of 225 ms at 3T.

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