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Abstract #1855

A new rapid and high-resolution multi-slice inhomogeneous Magnetization Transfer protocol to evaluate diffuse and regional cervical cord myelination at 3T

Henitsoa Rasoanandrianina1,2,3, Guillaume Duhamel1,2, Aurélien Massire1,2,3, Olivier Girard1,2, Maxime Guye1,2, Jean Pelletier1,2,4, Bertrand Audoin1,2,4, and Virginie Callot1,2,3

1Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, 2APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, 3iLab-Spine International Associated Laboratory, Montreal, Marseille, France, 4Department of Neurology, CHU Timone, AP-HM, Marseille, France

The inhomogeneous Magnetization Transfer (ihMT) technique has recently been proposed as a new method to probe the cervical spinal cord (CSC) myelin-content. Studies reported so far were limited to single-slice acquisition, hence precluding investigation of the whole CSC within a short acquisition time. To overcome this limitation, a 2D multi-slice single-shot Spin-Echo-Echo-Planar Imaging (SE-EPI) read-out approach was implemented at 3T along with strategies to correct for inherent susceptibility-induced image-distortions and post-saturation relaxation effect for each slice. Validated on phantom and applied to healthy subjects and a patient with multiple sclerosis, this preliminary study shows the promising value of SE-EPI ihMT in the clinical context.

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