Meeting Banner
Abstract #1854

Multicomponent relaxation analysis of myelin in the brains of rare progressive solitary sclerosis, compared to multiple sclerosis and healthy control subjects in vivo

Lisa Eunyoung Lee1, Jillian Chan1, Irene Vavasour2, Roger Tam2, Anthony Traboulsee1, Robert Carruthers1, and Shannon Kolind1,2

1Department of Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada, 2Department of Radiology, University of British Columbia, Vancouver, BC, Canada

Progressive solitary sclerosis (PSS) presents with an isolated demyelinating lesion along the corticospinal tract that results in progressive motor deficits. We used mcDESPOT-derived parameters to better understand the pathology in the normal-appearing white matter tracts (WMT) of PSS compared to relapsing-remitting multiple sclerosis (RRMS) and healthy control (HC) subjects. Overall, we found a trend of lower MWF (myelin content) and higher qT1 (inflammation/edema) in WMT in PSS, compared to RRMS and HC subjects. This suggested that there might be more extensive myelin damage in the normal-appearing brain, beyond the lesional site, that may be driving disease progression in PSS.

This abstract and the presentation materials are available to members only; a login is required.

Join Here