Abstract #1853

Sequential Changes of Diffusion Anisotropy and Mean Kurtosis in Cuprizone-Induced Demyelination: A Rat Model

Ping-Huei Tsai^1,2,3, Hua-Shan Liu⁴, Fei-Ting Hsu^1,2, Yu-Chieh Kao^1,3, Chia-Feng Lu^3,5, Hsiao-Wen Chung⁶, and Cheng-Yu Chen^1,2,3

¹Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ²Department of Medical Imaging, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan, ³Research Center of Translational Imaging, College of Medicine, Taipei Medical University, Taipei, Taiwan, ⁴School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan, ⁵Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ⁶Graduate Institute of Biomedical Electrics and Bioinformatics, National Taiwan University, Taipei, Taiwan

The verification of cuprizone-induced demyelination in a rat model remains controversial. This study aims to develop a reliable cuprizone-induced demyelination rat model and to test the ability of DKI to monitor the sequential changes during brain demyelination. Our findings demonstrated that DKI could provide complementary information, associated with pathophysiological processes after demyelination in rat brain, which may have potential to detect microstructural changes at both acute and chronic stages and contribute to evaluations of further therapeutic strategies.

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