Abstract #1857

Myelin-Water Quantification: Orthogonal Matching Pursuit versus Non-Negative Least Squares

Gerhard Drenthen^1,2, Walter Backes^1,2, Albert Aldenkamp³, and Jacobus Jansen^1,2

¹Department of Radiology & Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, ²School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, Netherlands, ³Department of Behavioral Sciences, Epilepsy Center Kempenheaghe, Heeze, Netherlands

Myelin-water quantification relies on modeling of multi-exponential T2-relaxation time decay. For this, we explore the greedy Orthogonal Matching Pursuit (OMP) method and compare it to the most commonly applied non-negative least squares (NNLS) method. The two methods are evaluated by means of simulations, phantom measurements and in vivo image data.

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