Abstract #1859

Training induced myelin and iron changes in healthy subjects using novel quantitative MRI techniques

Michela Azzarito¹, Eveline Huber¹, Maryam Seif¹, Gabriel Ziegler^2,3, and Patrick Freund^1,4,5,6

¹Spinal Cord Injury Center Balgrist, University Hospital Zurich, University of Zurich, Zurich, Switzerland, zürich, Switzerland, ²German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany , magdeburg, Germany, ³Institute of Cognitive Neurology and Dementia Research, Magdeburg, Germany , Magdeburg, Germany, ⁴Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, leipzig, Germany, ⁵Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, London, UK, london, United Kingdom, ⁶Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, University College London, London, UK, london, United Kingdom

Activity-dependent plasticity has significant implications for healthy development, learning, memory, and recovery from brain damage. However, the exact time course and the neural mechanisms behind brain plasticity are still not completely understood. In this study, longitudinal quantitative MRI protocols were used to assess training associated microstructural changes using markers sensitive to myelin and iron. We show that training improvements during a sensorimotor task performed over 4 weeks induces linear and non-linear increases in myelin and iron content in the primary motor cortex and cerebellum. This study provides new tools to assess training effects in healthy controls.

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