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Abstract #1867

Comparison between quantitative magnetization transfer imaging and ratio of T1w/T2w approach in myelin mapping

Yu Sui1, Pippa Storey1, Alexey Samsonov2, and Mariana Lazar1

1Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, 2Department of Radiology, University of Wisconsin at Madison, Madison, WI, United States

Myelination is one of the essential indicators of brain maturation, and various abnormalities in myelin content have been found for different psychiatric disorders. However, reliable imaging techniques for human in vivo myelin measurement are still under intensive research, thus the degree and significance of myelin deficits for specific pathology remain indeterminate. The current study compared myelin mapping proposed as part of the Human Connectome Protocol using the ratio of T1 and T2 weighted image intensity to quantitative magnetization transfer mapping (qMT). The relationship between myelin content estimated by these two methodologies in various brain regions is discussed.

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