A multiphysics model based on Navier-Stokes equation and continuity equation is built to simulate the arterial spin labeled (ASL) blood flow in the blood vessels. Blood velocity distribution is reconstructed by measuring the 4D time-resolved labeled blood concentration and doing inversion data fitting processing. The conventional lumped-element Kety’s equation provides a quantitative measurement of whole brain cerebral blood flow (CBF) suffering from the inaccurate estimation of arterial input function (AIF). The multiphysics model validates that the blood velocity involved vector field perfusion (VFP) with multiple post label delays does not rely on the AIF.
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