Abstract #1879

Vascular Change Assessed by Calibrated Multi-delay Arterial Spin Labeling Under Oxygen and Carbogen Gas Challenge

Michael L Rohan¹, Clara Wellons², Megan Shevenell³, Nicolette Schwarz⁴, Xingfeng Shao⁵, Daniel JJ Wang⁵, and Blaise Frederick³

¹Imaging, McLean Hospital, Belmont, MA, United States, ²imaging, McLean Hospital, Belmont, MA, United States, ³McLean Hospital, Belmont, MA, United States, ⁴Mc:ean Hospital, Belmont, MA, United States, ⁵University of Southern California, Los Angeles, CA, United States

Arterial Spin Labeling (ASL) measurements are employed here in a suite of hemodynamic assessments in our study of cerebrovascular reactivity. In this project we test a 3D Gradient and Spin Echo (GRASE) Multiple delay Pseudo-Continuous Arterial Spin Labeling (MPCASL) Magnetic Resonance (MR) acquisition in order to measure the change in these measures under gas challenge. Subjects were scanned with 3D GRASE MPCASL while breathing medical air, oxygen, or Carbogen (5% CO2 +95% O2) under controlled conditions. Changes in blood flow, volume, and arrival time that were observed will be used to calibrate novel delay assessment methods.

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