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Abstract #1879

Vascular Change Assessed by Calibrated Multi-delay Arterial Spin Labeling Under Oxygen and Carbogen Gas Challenge

Michael L Rohan1, Clara Wellons2, Megan Shevenell3, Nicolette Schwarz4, Xingfeng Shao5, Daniel JJ Wang5, and Blaise Frederick3

1Imaging, McLean Hospital, Belmont, MA, United States, 2imaging, McLean Hospital, Belmont, MA, United States, 3McLean Hospital, Belmont, MA, United States, 4Mc:ean Hospital, Belmont, MA, United States, 5University of Southern California, Los Angeles, CA, United States

Arterial Spin Labeling (ASL) measurements are employed here in a suite of hemodynamic assessments in our study of cerebrovascular reactivity. In this project we test a 3D Gradient and Spin Echo (GRASE) Multiple delay Pseudo-Continuous Arterial Spin Labeling (MPCASL) Magnetic Resonance (MR) acquisition in order to measure the change in these measures under gas challenge. Subjects were scanned with 3D GRASE MPCASL while breathing medical air, oxygen, or Carbogen (5% CO2 +95% O2) under controlled conditions. Changes in blood flow, volume, and arrival time that were observed will be used to calibrate novel delay assessment methods.

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