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Abstract #1896

Mean Transit Time as a Marker of Vascular Change in Asymptomatic White Matter Disease

Blake E. Dewey1,2, Xiang Xu2,3, Linda Knutsson3,4, Amod Jog5, Jerry L. Prince1,3, Peter B. Barker2,3, Peter C. M. van Zijl2,3, and Paul Nyquist6

1Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, United States, 2Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, United States, 4Department of Medical Radiation Physics, Lund University, Lund, Sweden, 5Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, MA, United States, 6Department of Neurology, Johns Hopkins University, Baltimore, MD, United States

White matter hyperintensity (WMH) has been associated with cognitive and motor decline. The condition is of presumed vascular origin and may involve decreased blood brain barrier (BBB) integrity. A double contrast injection scheme was used to access both dynamic contrast enhanced (DCE) and dynamic susceptibility contrast (DSC) perfusion-related parameters in an asymptomatic population with high prevalence of WMH. The mean transit time (MTT) was found to be significantly prolonged (5.87, p=0.002) in WMH when compared to normal appearing white matter and that there was no significant change in Ktrans (0.018, p=0.351) between the lesions and the white/gray matter.

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