Abstract #1926

Quantifying nigral degeneration indicates rapid eye movement sleep behavior disorder being a predictor of Parkinson's disease

hiroto takahashi¹, Yoshiyuki Watanabe², Masahito Mihara³, Hideki Mochizuki³, Hiroyoshi Adachi ⁴, Tian Liu⁵, Yi Wang ⁵, and Noriyuki Tomiyama²

¹Department of Radiology, Osaka University Graduate School of Medicine, Suita, Japan, ²Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine, Suita, Japan, ³Department of neurology, Osaka University Graduate School of Medicine, Suita, Japan, ⁴Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Japan, ⁵Departments of Biomedical Engineering and Radiology, Cornell University, New York, NY, United States

RBD is thought to be prodromal Parkinson's disease (PD), so we aimed to assess the utility of rapid eye movement sleep behavior disorder (RBD) as a predictor of PD using neuromelanin imaging and quantitative susceptibility mapping (QSM). Our results indicated that RBD-related dopamine cell loss and iron deposition in the substantia nigra pars compacta occur in the developmental process of PD. Thus, we conclude that RBD is prodromal PD and quantifying nigral degeneration in RBD is useful in predicting PD.

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