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Abstract #1925

The longitudinal changes in white matter of patients with Parkinson's disease as detected by using Fixel-Based Analysis

Shi-Ming Wang1, Sung-han Lin1, Chin-Song Lu2, Yi-Hsin Weng2, Yao-Liang Chen3, Shu-Hang Ng4, Yi-Ming Wu4, Chih-Chien Tsai1, Jacques-Donald Tournier5, and Jiun-Jie Wang1

1Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan, 2Neurology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, 3Diagnostic Radiology, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan, 4Diagnostic Radiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, 5Division of Imaging Sciences & Biomedical Engineering, King's College London, London, United Kingdom

Parkinson's disease (PD) is a neurodegenerative disease as the result from the loss of cell in basal ganglia. Fixel-Based Analysis can qualified the fiber density and fibre-bundle cross-section in the white matter. The fiber density and fibre-bundle cross-section is feasible to interpret the microstructure changes in the brain of patients with PD. Therefore, the current study aimed to investigate the long-term white matter changes in Parkinson's disease by using Fixel-Based Analysis.

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