Abstract #1925

The longitudinal changes in white matter of patients with Parkinson's disease as detected by using Fixel-Based Analysis

Shi-Ming Wang¹, Sung-han Lin¹, Chin-Song Lu², Yi-Hsin Weng², Yao-Liang Chen³, Shu-Hang Ng⁴, Yi-Ming Wu⁴, Chih-Chien Tsai¹, Jacques-Donald Tournier⁵, and Jiun-Jie Wang¹

¹Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan, ²Neurology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ³Diagnostic Radiology, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan, ⁴Diagnostic Radiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ⁵Division of Imaging Sciences & Biomedical Engineering, King's College London, London, United Kingdom

Parkinson's disease (PD) is a neurodegenerative disease as the result from the loss of cell in basal ganglia. Fixel-Based Analysis can qualified the fiber density and fibre-bundle cross-section in the white matter. The fiber density and fibre-bundle cross-section is feasible to interpret the microstructure changes in the brain of patients with PD. Therefore, the current study aimed to investigate the long-term white matter changes in Parkinson's disease by using Fixel-Based Analysis.

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