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Abstract #1924

Determination of White Matter Tracts Implicated in Postural Gait Instability Disorder through Tract-Based Automated Analysis

Leon Qi Rong Ooi1, Chu Ning Ann1, Yun-Chin Hsu2, Chen-Hsiang Weng2, Ming-Ching Wen1, HuiHua Li3, Helmut Rumpel4,5, Eng King Tan1,5,6, Wen-Yih Isaac Teng2,7, and Ling Ling Chan4,5

1Department of Research, National Neuroscience Institute, Singapore, Singapore, 2Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, 3Health Services Research Unit, Singapore General Hospital, Singapore, Singapore, 4Department of Diagnostic Radiology, Singapore General Hospital, Singapore, Singapore, 5Duke-NUS Medical School, Singapore, Singapore, 6Department of Neurology, Singapore General Hospital, Singapore, Singapore, 7Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

Tract-Based Automated Analysis (TBAA) in Diffusion Tensor Imaging allows for the study of microstructural properties along the tracts in white matter. Diffusivity measures extracted from TBAA for various tracts of the brain were correlated to Tinetti Balance Scale scores in Parkinson's Disease and Postural Gait Instability Disorder patients, allowing identification of tracts of interest in the pathological study of the diseases.

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