Reduced cerebral blood flow (CBF) is often blamed for sepsis-associated encephalopathy. The present study compares the CBF and blood oxygen consumption (CMRO2) of healthy subjects and resuscitated septic patients under vasopressor (norepinephrine) treatment. Methods used are pseudo-continuous arterial spin labeling (PCASL) and T2-relaxation-under-spin-tagging (TRUST). We find that septic patients have elevated global and regional CBF, whereas CMRO2 seems reduced. Further studies are needed to elucidate the underlying mechanisms of this apparent uncoupling.