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Abstract #1923

Cerebral blood flow in a resuscitated septic shock population: an ASL study

Marie Anne Richard1,2, Marie-Hélène Masse1,2, Frédérick D'Aragon1,2, Charles St-Arnaud1, Michael Mayette1, Steven Palanchuck1, Etienne Croteau1,2, Neil Adhikari3, William Fraser1,2, André Carpentier1,2, David Gauthier1, Luc Lanthier1, Matthieu Touchette1, Albert Lamontagne1, Jean Chénard1, Sangeeta Mehta4, Yanick Sansoucy1, François Lamontagne1,2, and Martin Lepage1,2

1Université de Sherbrooke, Sherbrooke, QC, Canada, 2Centre de recherche du CHUS, Sherbrooke, QC, Canada, 3Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 4Mount Sinai Hospital, Toronto, ON, Canada

Reduced cerebral blood flow (CBF) is often blamed for sepsis-associated encephalopathy. The present study compares the CBF and blood oxygen consumption (CMRO2) of healthy subjects and resuscitated septic patients under vasopressor (norepinephrine) treatment. Methods used are pseudo-continuous arterial spin labeling (PCASL) and T2-relaxation-under-spin-tagging (TRUST). We find that septic patients have elevated global and regional CBF, whereas CMRO2 seems reduced. Further studies are needed to elucidate the underlying mechanisms of this apparent uncoupling.

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