Despite advances in medications and modern practices of immediate antiretroviral therapy, chronic HIV infection remains associated with brain insults, cognitive decline, and related neurological disorders. Reduced N-acetyl-aspartete (NAA), a metabolic marker of neuronal injury, was associated with advanced age and lower CD4 nadir count in a chronic, asymptomatic HIV cohort. Using a novel, BOLD MR protocol incorporating hypercapnic and hyperoxic stimuli, NAA showed no relation to cerebrovascular reactivity (CVR) but was significantly correlated to cerebral blood volume (CBV). Our results may indicate future use of NAA and CBV as complementary non-invasive metrics to track brain health in HIV.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords