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Abstract #1930

Disrupted Functional Connectivity and Network Topology in Early Parkinson’s Disease

Karthik R Sreenivasan1, Virendra Mishra1, Zhengshi Yang1, Christopher Bird1, Xiaowei Zhuang1, Dietmar Cordes1,2, and Ryan R Walsh3

1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2University of Colorado Boulder, Boulder, CO, United States, 3Muhammad Ali Parkinson Center at Barrow Neurological Institute, Phoenix, AZ, United States

Imaging biomarkers that reliably capture the impact of the spreading pathology of Parkinson’s disease (PD), including its impact on both white and graymatter, remain elusive. In this study, we applied graph-theoretical techniques to multi-site resting-state fMRI data from a cohort of unmedicated early PD-subjects in Parkinson’s Progressive Markers Initiative (PPMI) database. Altered functional connectivity and disrupted topological brain organization was seen in early PD-subjects. Our study opens new avenues to understanding disease progression and severity of PD from graph-theoretical approach.

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