In this study, we investigated functional neural pathway organization in patients with Parkinson’s disease (PD) using advanced network-based techniques. At the regional network level, compared to controls, PD groups showed decreased functional connectivity within basal ganglia/sensorimotor network and parietal regions. Compared to early PD cases, mild-to-severe PD patients were characterized by a greater involvement of basal ganglia/sensorimotor networks. This study suggests that graph analysis and connectomics might represent a powerful approach to understand the pathophysiological process across different stages of the disease.
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