This preliminary study aims to explore high-resolution functional sensorimotor connectivity using resting-state fMRI in healthy controls (HC), Parkinson's (PD) and Huntington's (HD) disease patients. This 7T study therefore includes subjects showing all three states of the basal ganglia inhibitory function. Group ICA and dual regression analyses identified 2 sensorimotor networks: one in which PD and HD showed the same lower cortical connectivity pattern compared with HC in M1 (face area), but opposite pattern in the subthalamic nucleus; and another in which PD and HD showed opposite pattern in M1 and S1 (hand area). This demonstrates the capacity of 7T rs-fMRI to identify with remarkable detail meaningful differences between these two movement disorders.
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