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Abstract #1932

Sensorimotor resting-state functional connectivity at 7T: contrasting Huntington's and Parkinson's disease.

Sirius Boessenkool1, Stefania Evangelisti1, Patrick Pflanz1, Stuart Clare1, Campbell Le Heron2, Johannes Klein1, Richard Armstrong2, Kinan Muhammed2, Andrea Nemeth2, Michele Hu2, and Gwenaelle Douaud1

1FMRIB Centre, WIN, University of Oxford, Oxford, United Kingdom, 2NDCN, University of Oxford, Oxford, United Kingdom

This preliminary study aims to explore high-resolution functional sensorimotor connectivity using resting-state fMRI in healthy controls (HC), Parkinson's (PD) and Huntington's (HD) disease patients. This 7T study therefore includes subjects showing all three states of the basal ganglia inhibitory function. Group ICA and dual regression analyses identified 2 sensorimotor networks: one in which PD and HD showed the same lower cortical connectivity pattern compared with HC in M1 (face area), but opposite pattern in the subthalamic nucleus; and another in which PD and HD showed opposite pattern in M1 and S1 (hand area). This demonstrates the capacity of 7T rs-fMRI to identify with remarkable detail meaningful differences between these two movement disorders.

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