Fatiguability, an objective decline in the amplitude of movements during sustained or fast repetitive motor tasks, is one of the primary clinical features demonstrated in Parkinson’s disease (PD). However, our understanding of its underlying pathophysiology is still limited. Here, we propose a fMRI protocol to study the neuronal correlates of fatiguability and present preliminary data in PD and control subjects while performing sustained finger tapping. There was significant reduction of tapping-related activation in the primary motor cortex, somatosensory cortex, premotor cortex and middle frontal gyrus in the fatiguing vs. no-or-less fatiguing subgroups, suggesting that those regions were involved in fatigue.
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