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Abstract #1936

Brain Motor Asymmetry in PD using Positron Emission Tomography and Diffusion Tensor Imaging

Dan Stein1, Natalia Goldberg1, Liran Domachevsky 1, Hanna Bernstine1,2, Meital Nidam1, David Groshar1, Mordechai Lorberboym 1,3, Simon Israeli-Korn 4, Moshe Gomori5, Yaniv Assaf6, and Sharon Hassin-Baer2,7

1Assuta Medical Center, Tel-Aviv, Israel, 2Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel, 3Tel-Aviv University, Tel-Aviv, Israel, 4Movement Disorders Institute, Sagol Neuroscience Center and Department of Neurology, Chaim Sheba Medical Center, Tel Hashomer, Tel-Aviv, Israel, 5Department of Radiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Jerusalem, Israel, 6Sagol School of Neuroscience, Tel Aviv University, Tel-Aviv, Israel, 7Movement Disorders Institute, Sagol Neuroscience Center and Department of Neurology, Chaim Sheba Medical Center, Tel Hashomer, Israel, Tel-Aviv, Israel

The accuracy of clinical diagnosis of Parkinson disease is currently not satisfying, particularly in early Parkinson disease where clinical signs are not yet fully present. Imaging nigral structures has been proposed as a biomarker for PD but fails to provide effective differential diagnosis. In this study we compared motor brain regions between hemispheres in patients with asymmetrical motor symptoms using voxel based analysis and network analysis and have found significant regional differences between the more and less affected hemispheres as well as connectivity differences in frontal and cerebral regions as the main hubs.

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