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Abstract #1940

BOLD responses to light stimulus frequency in the rat visual pathway reveal profound effects of Parkinson’s disease in the Superior Colliculus

Emmanuelle Bellot1, Arnaud Pautrat1, Yassamine Rahmani Bouzina1, Nora Collomb2, Olivier Montigon2, Véronique Coizet1, and Michel Dojat1

1Grenoble Institut of Neurosciences, Inserm U1216, La Tronche, France, 2UMS Irmage, La Tronche, France

Sensory disorders are associated with Parkinson Disease (PD) at an early stage. We explored with fMRI the visual pathway response to light stimulus frequency in PD rat models. Activation of the Superior Colliculus (SC) was exacerbated at low frequency (1-3%) and rapidly saturated compared to controls. These results confirm the possible role of SC as an early biomarker of the disease.

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