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Abstract #1939

A Cycling Exercise Study of Parkinson’s Disease:  The Effect of Exercises on Motor Cortex Functional Connectivity Revealed by Resting State FMRI

Jian Lin1, Katherine A Koenig1, Erik Beall2, Mark J Lowe1, Amy E Jansen3, Amanda L Penko3, and Jay Alberts3

1Radiology, Cleveland Clinic, Cleveland, OH, United States, 2Hema Imaging LLC, Minneapolis, MN, United States, 3Biomedical Engineering, Cleveland Clinic, Cleveland, OH, United States

Parkinson’s disease (PD) is a progressive neurological disorder which produces a general poverty of movement. Lower extremity forced exercise (FE) has been shown to provide therapeutic benefits for PD motor symptoms similar to that of antiparkinson medication1. In the current study, both voluntary exercise (VE) and FE were evaluated. Our results suggest that both modes of aerobic exercise have effects on motor functional connectivity similar to changes associated with antiparkinson medication.

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