Abstract #1939

A Cycling Exercise Study of Parkinson’s Disease: The Effect of Exercises on Motor Cortex Functional Connectivity Revealed by Resting State FMRI

Jian Lin¹, Katherine A Koenig¹, Erik Beall², Mark J Lowe¹, Amy E Jansen³, Amanda L Penko³, and Jay Alberts³

¹Radiology, Cleveland Clinic, Cleveland, OH, United States, ²Hema Imaging LLC, Minneapolis, MN, United States, ³Biomedical Engineering, Cleveland Clinic, Cleveland, OH, United States

Parkinson’s disease (PD) is a progressive neurological disorder which produces a general poverty of movement. Lower extremity forced exercise (FE) has been shown to provide therapeutic benefits for PD motor symptoms similar to that of antiparkinson medication¹. In the current study, both voluntary exercise (VE) and FE were evaluated. Our results suggest that both modes of aerobic exercise have effects on motor functional connectivity similar to changes associated with antiparkinson medication.

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