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Abstract #1938

Validation of a 1.5T FSE NM-sensitive MRI sequence

Joana M Grilo1, Sofia Reimão2, Daisy Abreu3, Joaquim F Ferreira3,4, and Rita G Nunes1

1Bioengineering Department / Institute for Systems and Robotics, Instituto Superior Técnico, University of Lisbon, Lisbon, Portugal, 2Neurological Imaging Department, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon, Portugal, 3Clinical Pharmacology Unit, Instituto de Medicina Molecular, Faculdade de Medicina, University of Lisbon, Lisbon, Portugal, 4Neurology Department, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon, Portugal

Neuromelanin(NM)-sensitive MRI is a promising technique for enlightening pathological changes in NM-containing structures. Fast-Spin-Echo (FSE) based NM-MRI sequences have been applied at 3T for improved resolution and signal-to-noise ratio but scanner availability and safety concerns may prevent imaging at this field strength. A 1.5T NM-MRI FSE sequence was developed and compared to the standard 3T NM-MRI sequence. Semi-automatic segmentation of the Substantia Nigra (SN) was performed with good reliability at both fields. The Bland-Altman method was used to compare SN areas between field strengths showing good agreement, supporting the possibility for using NM-MRI at 1.5T, widening its scope of applicability.

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