Neuromelanin(NM)-sensitive MRI is a promising technique for enlightening pathological changes in NM-containing structures. Fast-Spin-Echo (FSE) based NM-MRI sequences have been applied at 3T for improved resolution and signal-to-noise ratio but scanner availability and safety concerns may prevent imaging at this field strength. A 1.5T NM-MRI FSE sequence was developed and compared to the standard 3T NM-MRI sequence. Semi-automatic segmentation of the Substantia Nigra (SN) was performed with good reliability at both fields. The Bland-Altman method was used to compare SN areas between field strengths showing good agreement, supporting the possibility for using NM-MRI at 1.5T, widening its scope of applicability.
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