In frontal lobe epilepsy (FLE) seizure onset is usually caused by the presence of lesions or cortical dysplasias of different location and size, challenging the identification of homogeneous samples for neuroimaging studies. However, there are patients in which, even if seizures start in the frontal lobe, no clearly identifiable abnormality can be seen on magnetic resonance imaging (MRI). Thus, it has been hypothesized that non-lesional FLE is indeed a network syndrome, rather the result of focal pathology. In the light of this, probabilistic tractography and graph analysis seem the ideal methodology to investigate the presence and extent of network alterations.
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