Abstract #1950

Functional connectivity changes during epileptogenesis: a longitudinal rs-fMRI study

Emma Christiaen¹, Marie-Gabrielle Goossens², Benedicte Descamps¹, Paul Boon², Robrecht Raedt², and Christian Vanhove¹

¹MEDISIP, Department of Electronics and Information Systems, Ghent University - IMEC, Ghent, Belgium, ²Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology (LCEN3), Department of Neurology, Ghent University, Ghent, Belgium

Abnormal functional brain networks could be involved in the development of temporal lobe epilepsy (TLE). In this longitudinal resting-state fMRI study, changes in functional networks during epileptogenesis in the intraperitoneal kainic acid (IPKA) rat model for TLE were mapped. Therefore, resting-state fMRI was acquired at several time points during epileptogenesis to identify functional networks that were analysed and compared with graph theory. Our results suggest that network connections in the functional brain network progressively become weaker during epileptogenesis. We also find a decreased segregation and integration of the network.

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