Resting-state functional connectivity of hippocampus in patients with drug-resistant idiopathic generalized epilepsy

Previous studies have found altered resting-state functional connectivity in default mode network in drug-resistant patients with idiopathic generalized epilepsy (IGE). Recent studies showed that the volume of the hippocampus is decreased in IGE patients. Hippocampus abnormalities are often related to drug-resistant epilepsy. We investigated the alteration of resting-state functional connectivity of hippocampus in drug-resistant IGE patients by using seed-based functional connectivity and found divergent changes in drug-resistant and drug-sensitive IGE patients. Our findings indicate that the hippocampus and the related network may play an important role in drug-resistant IGE patients.