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Abstract #1949

Resting-state functional connectivity of hippocampus in patients with drug-resistant idiopathic generalized epilepsy

Zhengge Wang1, Lipei Cao1, Bing Zhang1, and Bin Zhu1

1Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China

Previous studies have found altered resting-state functional connectivity in default mode network in drug-resistant patients with idiopathic generalized epilepsy (IGE). Recent studies showed that the volume of the hippocampus is decreased in IGE patients. Hippocampus abnormalities are often related to drug-resistant epilepsy. We investigated the alteration of resting-state functional connectivity of hippocampus in drug-resistant IGE patients by using seed-based functional connectivity and found divergent changes in drug-resistant and drug-sensitive IGE patients. Our findings indicate that the hippocampus and the related network may play an important role in drug-resistant IGE patients.

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