Abstract #1959

Comprehensive assessment of white matter microstructural integrity and its change across lifespan in patients with tuberous sclerosis complex

Tei-Wei Kao¹, Pi-Chuan Fan², Yung-Chin Hsu¹, and Wen-Yih Isaac Tseng^1,3

¹Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, ²Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ³Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

In previous studies, white matter microstructural integrity and its lifetime change in patients with tuberous sclerosis complex (TSC) were not clearly identified. Therefore, we performed diffusion spectrum imaging using whole-brain tract-specific analysis to measure the generalized fractional anisotropy (GFA), and built an age-GFA quadratic linear model to investigate 76 major white matter tract bundles between TSC and healthy control groups. Twenty tract bundles showed a group effect with substantially lower GFA in childhood and older adulthood in patients with TSC. Our results suggest that TSC might pose detrimental effects on microstructural integrity in the developmental and aging periods of life.

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