Abstract #1958

Setting up a Multi-centric Multiparametric hMRI Protocol for the Investigation of Temporal Lobe Epilepsy

Paul Summers¹, Fulvia Palesi², Francesco Padelli³, Ileana Zucca³, Marcella Malagoli⁴, Carmelo Maccagnano³, Stefano Meletti^4,5, Giuseppe Didato³, Claudia Wheeler-Kingshott^1,2,6, and Paolo Vitali¹

¹C. Mondino National Neurological Institute, Pavia, Italy, ²University of Pavia, Pavia, Italy, ³IRCCS Foundation, C. Besta Neurological Institute, Milan, Italy, ⁴Civile Aziende Ospedaliera-Universitaria, Modena, Italy, ⁵University of Modena and Reggio Emilia, Modena, Italy, ⁶University College London, London, United Kingdom

Quantitative characterization of MT, R1, R2*, and PD may aid in providing more consistent readings of alterations in temporal lobe epilepsy. As part of a multi-centric study we have set up a hMRI protocol for use at 3T across two manufactures of MR scanners. Because of differences in MT pulses and SAR calculations, near matching was achieved only through use of commercial or research options. Initial results from one scanner show excellent reproducibility within and between subjects for MT and R1. A cross-scanner evaluation is in course.

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