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Abstract #1958

Setting up a Multi-centric Multiparametric hMRI Protocol for the Investigation of Temporal Lobe Epilepsy

Paul Summers1, Fulvia Palesi2, Francesco Padelli3, Ileana Zucca3, Marcella Malagoli4, Carmelo Maccagnano3, Stefano Meletti4,5, Giuseppe Didato3, Claudia Wheeler-Kingshott1,2,6, and Paolo Vitali1

1C. Mondino National Neurological Institute, Pavia, Italy, 2University of Pavia, Pavia, Italy, 3IRCCS Foundation, C. Besta Neurological Institute, Milan, Italy, 4Civile Aziende Ospedaliera-Universitaria, Modena, Italy, 5University of Modena and Reggio Emilia, Modena, Italy, 6University College London, London, United Kingdom

Quantitative characterization of MT, R1, R2*, and PD may aid in providing more consistent readings of alterations in temporal lobe epilepsy. As part of a multi-centric study we have set up a hMRI protocol for use at 3T across two manufactures of MR scanners. Because of differences in MT pulses and SAR calculations, near matching was achieved only through use of commercial or research options. Initial results from one scanner show excellent reproducibility within and between subjects for MT and R1. A cross-scanner evaluation is in course.

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